Characterization of a cellular protease that cleaves Pseudomonas exotoxin
نویسندگان
چکیده
منابع مشابه
A remodelled protease that cleaves phosphotyrosine substrates.
Proteases are the largest family of enzymes in the human genome and play central roles in a wide range of physiological processes.1 To carry out these diverse functions, proteolytic enzymes have evolved highly tuned substrate specificities that allow them to degrade specific cellular proteins in response to appropriate signals. For many proteases, this specificity is encoded by the amino acid s...
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The adrenal gland requires stimuli from peptides derived from the ACTH precursor, pro-opiomelanocortin (POMC), to maintain its tonic state. Studies have proposed that a specific postsecretional cleavage of the nonmitogenic N-terminal 16 kDa fragment, also known as pro-gamma-melanotropin (pro-gamma-MSH), is required, releasing shorter fragments that promote adrenal growth. Here, we provide evide...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1992
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.60.2.497-502.1992